I was attending a short course taught by Susanne May on clinical trials (very good, by the way) and she mentioned an interesting publication. It talks about the “random high” bias. Continue reading
Referring to anecdotal data: “That’s not an experiment you have there, that’s an experience.” Sir Ronald A. Fisher.
I wanted to provide an overview of how you analyze a classic nonlinear regression model. It is a difference of two exponential functions. This nonlinear function is used commonly in pharmocokinetic models and is a simply way to model the oral administration of a drug. I want to show how the model works in a mathematical sense and then how you fit it using R. Continue reading