Recommended: Conducting Clinical Research

This is a website associated with a very nice book on the pragmatic aspects of running a clinical trial. I came across this site because I was looking for a simple example of a letter to doctors asking them to help recruit patients for a clinical trial. This was in an appendix along with other nice examples of things like case report forms, serious adverse event forms, HIPAA consent template, etc. You can download a free PDF version of this book or you can buy a paper copy. Continue reading

PMean: Cases and cohorts and controls, oh my!

Some asked a question about a retrospective study where you have a control cohort matched to a case cohort so the cohorts are similar on important (potentially confounding) variables. I pointed out that the two consecutive words “case cohort” are ambiguous and tried to explain  how I define a retrospective cohort design versus a (retrospective) case-control design. Continue reading

PMean: How to run your first Bayesian analysis using jags software in R

Someone wanted to know how to run a Bayesian data analysis for a two group longitudinal study. There are several ways you can do this, but I had to confess I did not have an immediate answer. So I took some time to figure out how to do this using jags software inside of R. I’ve done a fair amount of stuff in jags, but not anything close to a longitudinal design. The general principle is to start with something easy and work your way slowly up to the final analysis. Continue reading