PMean » Blinding in research http://blog.pmean.com A blog about statistics, evidence-based medicine, and research ethics Sat, 22 Jun 2024 17:10:26 +0000 en-US hourly 1 https://wordpress.org/?v=3.7.41 Recommended: Blind analysis: Hide results to seek the truth http://blog.pmean.com/triple-blind/ http://blog.pmean.com/triple-blind/#comments Tue, 11 Apr 2017 23:39:32 +0000 http://blog.pmean.com/?p=1064 This page is moving to a new website.

This paper advocates something I would call a triple blind, keeping the doctor, the patient, and the statistician who analyzes the data in the dark as to which treatment group is which. This avoids problems where the people analyzing the data will either consciously or subconsciously manipulate the data to get a preferred result. Interesting idea, though it represents an awful amount of work to pull it off.

Robert MacCoun, Saul Perlmutter. Blind analysis: Hide results to seek the truth. Nature 2015 (October 7), 526(7572), 187-189. Available at http://www.nature.com/news/blind-analysis-hide-results-to-seek-the-truth-1.18510.

]]> http://blog.pmean.com/triple-blind/feed/ 0 Recommended: Safeguarding Patients in Clinical Trials with High Mortality Rates http://blog.pmean.com/safeguarding/ http://blog.pmean.com/safeguarding/#comments Wed, 02 Dec 2015 22:01:49 +0000 http://blog.pmean.com/?p=571 This is an article the I would trot out if anyone tried to argue that a Data Safety and Monitoring Board should, like the investigators, be blinded as to treatment status during their deliberations.

BRADLEY D. FREEMAN, ROBERT L. DANNER, STEVEN M. BANKS, and CHARLES NATANSON “Safeguarding Patients in Clinical Trials with High Mortality Rates”, American Journal of Respiratory and Critical Care Medicine, Vol. 164, No. 2 (2001), pp. 190-192. doi: 10.1164/ajrccm.164.2.2011028. Available at http://www.atsjournals.org/doi/full/10.1164/ajrccm.164.2.2011028.

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